Abstract: Nine compounds were obtained from the fermentation broth of the Arctic-derived fungus Articulospora sp. Z1-1 and Penicillium sp. S-1-10. The broth extract was isolated and purified by column chromatography on silica -gel, Sephadex LH-20 and HPLC. The structures were elucidated by physical and chemical properties and spectral analysis, and comparison with the data of literatures. The nine compounds were identified as 3,7-dihydroxy-9 -methoxy-1-methyl-benzo[c]chromen-6-one (1), 1,4-dihydroxytoluene (2), 3-hydroylmethy phenol(3), 2-hydroxyphenethyl alcohol (4), dibutyl phthalate (5), 1,7-dihydroxy-3-hydroxyl-8methyl-dibenzo[b, e] oxepine-13, 14-dion -e (6), bis (2-ethylhexyl) phthalate (7), 4-tridecyl-benzaldehyde (8) and (Z)-7-tetradecenoic acid (9). Compounds 1–6 were firstly isolated from Articulospora sp. Z1-1 and compound 8 was new natural product. Compound 1 and 4 exhibited antifungal activity against conidia of Pyricularia oryzae, and compound 2 was shown to have antifungal and cytotoxic activity, and compound 3 exhibited strong antioxidant activity.

Key words: Arctic-derived fungus, Articulospora sp.Z1-1, Penicillium sp.S-1-10, secondary metabolites, biological activities