Chinese Journal of Polar Research ›› 2020, Vol. 32 ›› Issue (1): 60-67.DOI: 10.13679/j.jdyj.20190020

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Secondary metabolites from the Antarctic fungi Cladosporium sp. NJF4 and NJF6

Chang Junnan1,2, Tian Xiaoqing2, Fan Chengqi2, Huang Jinchang2, Lu Yanan2, Han Qinghua2   

  1. 1.Shanghai Ocean University, Shanghai 201306, China;
    2.Key Laboratory of East China Sea & Oceanic Fishery Resources Exploitation and Utilization, Ministry of Agriculture, East China Sea Fisheries Research Institute, Shanghai 200090, China
  • Received:2019-04-11 Revised:2019-05-13 Online:2020-03-30 Published:2020-03-30

Abstract:

Antarctic microorganisms exhibit considerable uniqueness and biodiversity because of their harsh and special habitat. Their secondary metabolites have become an important source of bioactive substances. Research on polar microbial secondary metabolites has gradually increased in recent years, but still lags behind temperate and tropical microbial research. We conducted chemical analyses on two fungi (Cladosporium sp. NJF4 and NJF6) in marine sediments from Prydz Bay, Antarctica. Twenty compounds were isolated, including sterol (1), sesquiterpenes (7—8), alkaloids (9—14), diketopiperazines (2—5, 15—17), and aromatic acids (6, 18—19). The sesquiterpenoids (7—8) were isolated from this genus for the first time. This study provides a new theoretical basis to fully exploit the metabolic potential of the Antarctic microorganisms, and will play an important role in promoting research on the medicinal value of polar microbial resources.

Key words: Antarctic fungi, secondary metabolites, isolation and purification, structural identification