ADVANCES IN POLAR SCIENCE ›› 2016, Vol. 28 ›› Issue (3): 331-335.DOI: 10.13679/j.jdyj.2016.3.33
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Jiang Shengping1,2,Tian Xiaoqing1,Liao Li3,Yang Qiao1,Lu Yanan1,Ma Liyan1,Chen Bo3,Fan Chengqi1
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Abstract: Various types of constituents, including aromatic nitro compounds, peptides, and terpenoids, have been reported from different polar microorganisms. In our investigation of secondary metabolites of Arctic actinomycete with new structures or potent bioactivity, five antimycin A derivatives, Antimycin A1b (1), Antimycin A4a (2), Antimycin A2a (3), Antimycin A3a (4), Antimycin A1a (5), together with Vulgamycin (6) and its derivative 8-deoxyenterocin (7), were obtained from Streptomyces sp. 604F. The compounds were purified by Sephadex LH-20 column chromatography and semi-preparative high-performance liquid chromatography, and their structures were determined by comparing their liquid chromatograph-mass spectrometry and 1H- and 13C-NMR data with those of previously reported compounds. This is the first report of compounds 1—7 from microbes derived from Arctic sediment, and it is the first time that antimycin and vulgamycin compounds were identified as metabolites from the same source.
Key words: Arctic actinomycete, Streptomyces sp. 604F, Antimycina, Vulgamycin
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URL: https://journal.chinare.org.cn/EN/10.13679/j.jdyj.2016.3.33
https://journal.chinare.org.cn/EN/Y2016/V28/I3/331