极地研究

极地研究

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Evaluation of the biological toxicity of fluorine in Antarctic krill

ZHANG Ling1,2, LU Xiaoqi1,2, WANG Zhangmin1,2, QIN Liqiang3, LIN Zhiqin4, YUAN Linxi2, ZHANG Wen5 & YIN Xuebin1,2*   

  1. 1 School of Earth and Space Science, University of Science and Technology of China, Hefei 230026, China;
    2 Suzhou Key Lab for Eco-safety and Human Health, Suzhou Institute for Advanced Study, University of Science and
    Technology of China, Suzhou 215123, China;
    3 Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou 215123, China;
    4 Environmental Sciences Program, Southern Illinois University, Edwardsville, Illinois 62026, USA;
    5 Department of Orthopedics Research Institute, Soochow University, Suzhou 215006, China
  • 出版日期:1964-03-30 发布日期:1964-03-30

Evaluation of the biological toxicity of fluorine in Antarctic krill

ZHANG Ling1,2, LU Xiaoqi1,2, WANG Zhangmin1,2, QIN Liqiang3, LIN Zhiqin4, YUAN Linxi2, ZHANG Wen5 & YIN Xuebin1,2*   

  1. 1 School of Earth and Space Science, University of Science and Technology of China, Hefei 230026, China;
    2 Suzhou Key Lab for Eco-safety and Human Health, Suzhou Institute for Advanced Study, University of Science and
    Technology of China, Suzhou 215123, China;
    3 Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou 215123, China;
    4 Environmental Sciences Program, Southern Illinois University, Edwardsville, Illinois 62026, USA;
    5 Department of Orthopedics Research Institute, Soochow University, Suzhou 215006, China
  • Online:1964-03-30 Published:1964-03-30

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摘要： Antarctic krill is a potentially nutritious food source for humans, but fluorine (F) toxicity is a matter of concern. To evaluate the toxicity of F in Antarctic krill, 30 Wistar rats were divided into three groups with different dietary regimens: a control group, a krill treatment group (150 mg·kg−1 F), and a sodium fluoride (NaF) treatment group (150 mg·kg−1 F). After three months, F concentrations in feces, plasma, and bone were determined, and the degree of dental and skeletal fluorosis was assessed. The F concentrations in plasma and bone from the krill treatment group were 0.167 0±0.020 4 mg.L−1 and 2 709.8±301.9 mg·kg−1, respectively, compared with 0.043 8±0.005 5 mg·L−1 and 442.4±60.7 mg·kg−1, respectively, in samples from the control group. Concentrations of F in plasma and bone in the krill treatment group were higher than in the control group, but lower than in the NaF treatment group. The degree of dental fluorosis in the krill treatment group was moderate, compared with severe in the NaF treatment group and normal in the control group. The degree of skeletal fluorosis did not change significantly in any group. These results showed that the toxicity of F in Antarctic krill was lower than for an equivalent concentration of F in NaF, but it was toxic for rats consuming krill in large quantities. To conclude, we discuss possible reasons for the reduced toxicity of F in Antarctic krill. The present study provides a direct toxicological reference for the consideration of Antarctic krill for human consumption.

关键词: Antarctic krill, fluorine (F), fluorosis, rat experiment, toxicological effect

Abstract: Antarctic krill is a potentially nutritious food source for humans, but fluorine (F) toxicity is a matter of concern. To evaluate the toxicity of F in Antarctic krill, 30 Wistar rats were divided into three groups with different dietary regimens: a control group, a krill treatment group (150 mg·kg−1 F), and a sodium fluoride (NaF) treatment group (150 mg·kg−1 F). After three months, F concentrations in feces, plasma, and bone were determined, and the degree of dental and skeletal fluorosis was assessed. The F concentrations in plasma and bone from the krill treatment group were 0.167 0±0.020 4 mg.L−1 and 2 709.8±301.9 mg·kg−1, respectively, compared with 0.043 8±0.005 5 mg·L−1 and 442.4±60.7 mg·kg−1, respectively, in samples from the control group. Concentrations of F in plasma and bone in the krill treatment group were higher than in the control group, but lower than in the NaF treatment group. The degree of dental fluorosis in the krill treatment group was moderate, compared with severe in the NaF treatment group and normal in the control group. The degree of skeletal fluorosis did not change significantly in any group. These results showed that the toxicity of F in Antarctic krill was lower than for an equivalent concentration of F in NaF, but it was toxic for rats consuming krill in large quantities. To conclude, we discuss possible reasons for the reduced toxicity of F in Antarctic krill. The present study provides a direct toxicological reference for the consideration of Antarctic krill for human consumption.

Key words: Antarctic krill, fluorine (F), fluorosis, rat experiment, toxicological effect